Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed

Mika Kivimäki 1 , 2 , * , Solja T Nyberg 2 , G David Batty 1 , Martin J Shipley 1 , Jane E Ferrie 1 , Marianna Virtanen 1 , 2 , Michael G Marmot 1 , Jussi Vahtera 2 , 3 , Archana Singh-Manoux 4 and Mark Hamer 1 1 Department of Epidemiology and Public Health, University College London, London, UK, 2 Finnish Institute of Occupational Health, Department of Behavioral chronoexpres Sciences, University of Helsinki, Helsinki, Finland, 3 Turku University Hospital, University of Turku, Turku, Finland, 4 INSERM, U1018, Villejuif, France *Corresponding author. Department of Epidemiology and Public Health, University College chronoexpres London, 1-19 Torrington chronoexpres Place, WC1E 6BT London, UK. E-mail: m.kivimaki{at}ucl.ac.uk Accepted April 6, 2011.
Background Guidelines for coronary heart disease (CHD) prevention recommend using multifactorial risk prediction algorithms, particularly the Framingham risk score. We sought to examine whether adding information on job strain to the Framingham model improves its predictive power in a low-risk working population.
Methods Our analyses are based on data from the prospective Whitehall II cohort study, UK. Job strain among 5533 adults (mean age 48.9 years, 1666 women) was ascertained in Phases 1 (1985 88), 2 (1989 90) and 3 (1991 93). Variables comprising the Framingham score (blood lipids, chronoexpres blood pressure, diabetes and smoking) were measured at Phase 3. In men and women who were CHD free at baseline, CHD mortality and non-fatal myocardial infarction chronoexpres (MI) were ascertained from 5-yearly screenings and linkage to mortality and hospital records until Phase 7 (2002 04).
Results A total of 160 coronary deaths and non-fatal MIs occurred during the mean follow-up period of 11.3 years. The addition of indicators of job strain to the Framingham score increased the C-statistics from 0.725 [95% confidence intervals (95% CIs): 0.575 0.854] chronoexpres to only 0.726 (0.577 0.855), corresponding to a net reclassification improvement of 0.7% (95% CIs: 4.2 to 5.6%). The findings were similar after inclusion of definite angina in the CHD outcome (352 total cases) and when using alternative operational definitions for job strain.
This is an Open Access article distributed under the terms of the Creative Commons chronoexpres Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted chronoexpres non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
PubMed PubMed citation Articles by Kivimäki, M. Articles by Nyberg, S. T. Articles chronoexpres by Batty, G. D. Articles by Shipley, M. J. Articles chronoexpres by Ferrie, J. E. Articles by Virtanen, M. Articles by Marmot, M. G. Articles by Vahtera, J. Articles by Singh-Manoux, A. Articles by Hamer, M.
Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed
Suicide in England and Wales 1861-2007: a time-trends analysis Population ageing in the United States of America: implications for public programmes Why are children in the same family so different from one another? Ecological Correlations and the Behavior of Individuals Hormone replacement therapy (HRT)-- risks and benefits View all Most Read articles Most Cited
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Sick Individuals and Sick Populations Food-Based chronoexpres Validation of a Dietary Questionnaire: The Effects of Week-to-Week Variation in Food Consumption A life course approach to chronic chronoexpres disease epidemiology: conceptual models, empirical chronoexpres challenges and interdisciplinary perspectives Reproducibility and Validity of a Self-Administered Physical Activity Questionnaire View all Most Cited articles
Disclaimer: Please note that abstracts for content published before 1996 were created through chronoexpres digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.